11 και 12 Σεπτεμβρίου
Στις 11-12 Σεπτεμβρίου 2014, θα πραγματοποιηθεί στο Συνεδριακό και Πολιτιστικό Κέντρο του Πανεπιστημίου Πατρών Διεθνές Συμπόσιο με τίτλο “Views into nuclear function”. Στο Συμπόσιο θα συζητηθούν πρόσφατα ευρήματα για τη ρύθμιση της έκφρασης των γονιδίων και την επίδρασή της στη φυσιολογική λειτουργία των βλαστικών κυττάρων.
Στο Συμπόσιο συμμετέχουν κορυφαίοι επιστήμονες από την Ευρώπη, τις ΗΠΑ και την Ιαπωνία και απευθύνεται σε φοιτητές και ερευνητές του Πανεπιστημίου ενώ θα συμμετέχουν ερευνητές από την Ευρώπη, τις ΗΠΑ, το Ισραήλ, την Ινδία και την Ιαπωνία.
Για περισσότερες πληροφορίες μπορείτε να απευθυνθείτε στον Σ. Ταραβήρα Αναπληρωτή Καθηγητή της Ιατρικής Σχολής του Πανεπιστημίου Πατρών στην ηλεκτρονική διεύθυνση [email protected] και στο τηλέφωνο 2610997943, καθώς και στον ιστότοπο του συνεδρίου στο http://www.nuclearfunction.upatras.gr/
Το πρόγραμμα του Συμποσίου, όπως ανακοινώθηκε από το Πανεπιστήμιο Πατρών, έχει ως εξής:
Views into Nuclear Function 11-12 September 2014 Cultural and Conference Center, University of Patras
Thursday September 11, 2014
08:15 -08:45 Registration
08:45 -09:00 Symposium Opening
Venetsana Kyriazopoulou, Professor
Rector of the University of Patras
Session I: Transcriptional Regulation and Cell Fate Choices Chair: Carol Murphy, Yoshihiro Takihara
09:00 – 09:30 New players in stem cell fate commitment decisions
Stavros Taraviras Stem Cell Laboratory, Department of Physiology, Medical School, University of Patras, Greece
09:30 - 10:00 Molecular role for Geminin in governing Hematopoietic Stem Cell activity
Yoshihiro Takihara Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine,
Hiroshima University, Japan
10:00 - 10:30 Growth factor receptor signalling and intracellular membrane trafficking
Carol Murphy FORTH, Biomedical Research Institute, Ioannina, Greece
10:30 - 10:45 Regulation of nuclear complex formation and transport of HIF-1α and its role in metabolic adaptation of cancer
cells to hypoxia
George Simos Department of Biochemistry, Medical School, University of Thessaly, Greece
10:45 - 11:00 Human nuclear RNase P is part of initiation complexes of RNA polymerase III: Coordination of transcription and
processing of tRNA.
Nayef Jarrous Department of Microbiology and Molecular Genetics, IMRIC, School of Medicine, The Hebrew
University-Hadassah, Jerusalem, Israel
11:00 - 11:30 Coffee Break
Session II: Chromatin and Nuclear Organization Chair: Dave M. Gilbert, J. Julian Blow
11:30 -12:00 Hierarchical re-organization of chromatin during early G1 reflects temporal and developmental control of DNA
replication
Dave M. Gilbert Department of Biological Science, The Florida State University, Florida, USA
12:00 - 12:30 Interdependence of the chromosome condensation-decondensation cycle with DNA replication in C. elegans
embryos
Julian Blow Centre for Gene Regulation and Expression, College of Life Science, University of Dundee, UK
12:30 - 13:00 Quantitative imaging of chromosome segregation dynamics in yeast model systems
Christian H. Haering Cell Biology and Biophysics Unit, Structural and Computational Biology Unit, EMBL,
Heidelberg, Germany
13:00 - 13:15 Nuclear dynamics in laminopathy cells
Winnok DeVos Department of Molecular Biotechnology, Ghent University, Gent, Belgium
13:15 - 13:30 Reb1 protein, from replication blockage to transcription regulation
María Rodríguez-López Research Department of Genetics, Evolution and Environment, University College
London, UK
13:30 - 15:00 Lunch Break and Poster Viewing
15:00 - 15:30 Super-Resolution Microscopy: New Dimensions in STED Imaging
Gabriele Burger Leica Microsystems, Mannheim, Germany
Session III: Stem Cells, Development and Regeneration Chair: Colette Dehay, Takashi Hiiragi
15:30 - 16:00 Symmetry breaking in mouse development
Takashi Hiiragi Developmental Biology Unit, EMBL, Heidelberg, Germany
16:00 - 16:30 Importance of cell-cycle regulation for evo/devo of the cerebral cortex
Colette Dehay Stem-cell and Brain Research Institute, Lyon, France
16:30 - 17:00 Chromatin in neuronal programming and reprogramming
Jovica Ninkovic Institute of Stem Cell Research, Helmholtz Center Munich, Munich, Germany
17:00 - 17:15 Co-ordinated regulation of cell cycle, neurogenesis and astrogliogenesis by nuclear receptor NR5A2 during neural
development
Panagiotis Politis Center for Basic Research, Biomedical Research Foundation of the Academy of Athens,
Greece
17:15 – 17:30 Gypsy insulator containing transgenes display transvection
Pawel Piwko Institute of Molecular Biology & Biotechnology FORTH and Dept of Biology, University of Crete,
Heraklion, Greece
17:30 - 18:00 Coffee Break
Session IV: Origins and Genome Stability Chair: Jenny Wu, John Diffley
18:00 - 18:30 Mechanism, Regulation and Misregulation of DNA Replication Origin Firing
John Diffley Clare Hall Laboratories, London Research Institute, London, UK
18:30 - 19:00 Impact of replication origin selection on cellular physiology
Jenny Wu Institute of Genetics and Development, Faculty of Medicine, Rennes, France
19:00 –19:30 From genome integrity to genome plasticity: DNA replication licensing aberrations
Zoi Lygerou Cell Cycle Laboratory, Department of General Biology, Medical School, University of Patras, Greece
19:30- 19:45 Molecular mechanisms underlying oncogene-dependent replication stress
Gaetano Ivan Dellino Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
End of day one
Friday September 12, 2014
Session V: Replication and DNA Damage Chair: Maria Fousteri, Wojciech Niedzwiedz
09:00 – 9:30 TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
Wojciech Niedzwiedz The Weatherall Institute of Molecular Medicin, University of Oxford, John Radcliffe
Hospital, Headington, Oxford
09:30 - 10:00 Chromosome Kissing and Replicative Life Span
Deepak Bastia Department of Biochemistry and Molecular Biology, Medical University of South Carolina,
Charleston, USA
10:00 - 10:15 Polyubiquitylation drives replicative helicase disassembly at the termination of eukaryotic replication forks
Aga Gambus Chromosomal Replication Laboratory, School of Cancer Sciences, University of Birmingham,
Edgbaston, Birmingham, UK
10:15 - 10:30 RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2 mediated phosphorylation of BRCA2
Dafni E. Pefani Department of Oncology, Cancer Research UK/MRC Oxford Institute, University of Oxford, UK
10:30 - 10:45 Regulating DNA replication: H4K20me1 is part of it!
Nina Kirstein Department of Gene Vectors, Research Group DNA Replication, Institute of Stem Cell Research,
Helmholtz Center Munich, Munich, Germany
10:45 - 11:15 Coffee Break
Session VI: Gene Expression and Epigenetic Regulation Chair: Peter Fraser, Spiros Georgatos
11:15 - 11:45 From cell populations to single molecule analysis of chromosome folding
Peter Fraser Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK
11:45- 12:15 HP1 dynamics reports a shifting continuum of chromatin states in pluripotent and terminally differentiated cells
Spyros Georgatos Department of Biochemistry, Medical School, University of Ioannina, Greece
12:15 - 12:45 Estimation and control of cell populations
John Lygeros Automatic Control Laboratory, ETH Zurich, Switzerland
12:45 - 13:00 Cdc23/Mcm10 Cooperates with Polα to Generate the Lagging Strand Imprint to Facilitate Cell Fate Determination
in Fission Yeast
Jagmohan Singh Institute of Microbial Technology, Chandigarh, India
13:00 – 14:30 Lunch Break and Poster Viewing
14:30 - 15:00 Scientific publishing- towards a useful, reliable literature
Esther Schnapp Editor EMBO Report, EMBO, Heidelberg, Germany
Session VII: Cell Reprogramming Chair: Maria Pia Cosma, Eirini Papapetrou
15:00 - 15:30 Visualizing nucleosome organization in pluripotent stem cells
Maria Pia Cosma Reprogramming and Regeneration Group, Center for Genomic Regulation, Barcelona, Spain
15:30 - 16:00 Functional dissection of chromosome 7q loss associated with myeloid malignancies using isogenic human
pluripotent stem cell models
Eirini Papapetrou Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New
York, USA
16:00 - 16:15 iSox2 accelerates lineage reprogramming
Morfoula Remboutsika Stem Cell Biology Laboratory, Biomedical Sciences Research Centre “Alexander
Fleming”, Athens, Greece
16:15 - 16:30 Hypomethylating agents induce immunoregulatory T cells
Panagiota Stamou Bone Marrow Transplantation Unit, University Hospital of Patras, Patras, Greece
16:30 - 16:45 Epigenetic regulation of “Aged” genome
Teimuraz Lezhava Department of Genetics, Tbilisi State University, Tbilisi, Georgia
16:45 –17:15 Coffee Break
Session VIII: Cell Cycle Control Chair: Nicoletta Sacchi, Erich Nigg
17:15 - 17:45 Cell Cycle Control of Chromosome Segregation
Erich Nigg The Center of Molecular Life Sciences, University of Basel, Biozentrum, Basel, Switzerland
17:45 - 18:15 Operation and regulation of synthetic cell cycles
Damien Coudreuse Institute of Genetics and Development, Faculty of Medicine, Rennes, France
18:15 - 18:45 Nuclear organization of centromeres
Patrick Heun Centre for Biological Signalling Studies, Albert-Ludwigs-University of Freiburg, Freiburg, Germany
18:45 - 19:15 Imaging a cell autonomous RARA mechanism that determines disparate retinoic acid actions in development and
cancer
Nicoletta Sacchi Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA
19:15-19:30 Concluding remarks
End of Meeting
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